Once cancer spreads in the body and forms metastases, the initial treatment plan is likely to change according to the number, size, and location of the metastases. Most of the times, doctors recommend a combination of surgery, chemotherapy, and radiation. However, palliative treatments are preferred when cancer has metastasized as they ease the pain and improve the quality of life. An oncologist who is experienced in treating mesothelioma can suggest the best treatment option both for initial cancer and the metastases.