Fibulin-3 is a protein biomarker found in pleural fluid and blood, which seems to reliably determine the presence or absence of mesothelioma cancer cell. Further research is necessary to establish the diagnostic and prognosis value of fibulin-3. The difference between the mesothelin protein and fibulin-3 in diagnosing the mesothelioma is still observed and researched. So far it has been observed that mesothelin remains a more precise biomarker of mesothelioma, whilst fibulin-3 is a more useful predictor of mesothelioma survival (less fibulin-3 present in the pleural effusion, longer the survival period.